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Front Cover: Soyasaponin A 2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline‐Deficient (MCD) Diet‐induced Nonalcoholic Steatohepatitis (NASH) Mice
Author(s) -
Xiong Fei,
Zheng Zhongdaixi,
Xiao Lingyu,
Su Chuhong,
Chen Junbin,
Gu Xiangfu,
Tang Jiaqi,
Zhao Yue,
Luo Huiyu,
Zha Longying
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202170033
Subject(s) - steatohepatitis , methionine , gut flora , nonalcoholic steatohepatitis , farnesoid x receptor , g protein coupled bile acid receptor , medicine , choline , endocrinology , bile acid , fgf21 , chemistry , biochemistry , biology , fibroblast growth factor , receptor , fatty liver , nonalcoholic fatty liver disease , amino acid , disease , nuclear receptor , transcription factor , gene
Mol. Nutr. Food Res . 2021, 65 , 2100067 DOI: 10.1002/mnfr.202100067 Soyasaponin A 2 alleviates steatohepatitis by modulating the gut microbiota composition, altering the bile acids profiles in liver and serum, and increasing the ileum expression of Farnesoid X receptor (FXR) and fibroblast growth factor (FGF‐15) in the methionine and choline deficient diet‐induced non‐alcoholic steatohepatitis (NASH) mice. This is reported by Longying Zha and co‐workers in article number 2100067.