Front Cover: Methylglyoxal‐Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells | Zendy

Lee HeeWeon | Zendy; Gu Min Ji | Zendy; Lee JeeYoung | Zendy; Lee Seungju | Zendy; Kim Yoonsook | Zendy; Ha Sang Keun | Zendy

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Front Cover: Methylglyoxal‐Lysine Dimer, an Advanced Glycation End Product, Induces Inflammation via Interaction with RAGE in Mesangial Cells

Author(s) -

Lee HeeWeon,

Gu Min Ji,

Lee JeeYoung,

Lee Seungju,

Kim Yoonsook,

Ha Sang Keun

Publication year - 2021

Publication title -

molecular nutrition and food research

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.495

H-Index - 131

eISSN - 1613-4133

pISSN - 1613-4125

DOI - 10.1002/mnfr.202170031

Subject(s) - methylglyoxal , glycation , advanced glycation end product , mesangial cell , rage (emotion) , chemistry , reactive oxygen species , lysine , lactoylglutathione lyase , inflammation , biochemistry , receptor , microbiology and biotechnology , immunology , biology , amino acid , enzyme , neuroscience , in vitro

Mol. Nutr. Food Res . 2021, 65 , 2000799 DOI: 10.1002/mnfr.202000799 Methylglyoxal‐lysine dimer, a typical advanced glycation end product, contributes to inflammatory responses during renal disorder. The interaction of Methylglyoxal‐lysine dimer (MOLD) and receptor of advanced glycation end products (RAGE) causes reactive oxygen species (ROS) production and mitochondrial dysfunction in mesangial cells. Further, the NF‐kB and PI3K/AKT signaling pathways triggered by ROS exacerbate the inflammatory responses in MOLD‐induced renal damages. This is reported by Sang Keun Ha and co‐workes in article number 2000799.

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