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Front Cover: Suppression of Hippo Pathway by Food Allergen Exacerbates Intestinal Epithelia Instability and Facilitates Hypersensitivity
Author(s) -
Wang Chong,
lin Wanglei,
Wang Yanbo,
Fu Linglin
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202170006
Subject(s) - allergen , microbiology and biotechnology , hippo signaling pathway , immunology , biology , innate immune system , in vivo , allergy , food allergens , immune system , signal transduction , genetics
Mol. Nutr. Food Res . 2021, 65 , 2000593 DOI: 10.1002/mnfr.202000593 Hippo signaling is a crucial pathway in innate immune responses. In this study, both in vivo and in vitro data revealed that the suppression of Hippo pathway by food allergen exacerbates intestinal epithelia instability and facilitates hypersensitivity. TAZ is a crucial protein regulating Hippo‐mediated food allergy, and depletion of TAZ blocked allergen‐induced epithelial allergic responses. This is reported by Chong Wang, Wanglei lin Yanbo, and Wang Linglin Fu in article 2000593.