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Back Cover: β‐1,3/1,6‐Glucans and Immunity: State of the Art and Future Directions
Author(s) -
De Marco Castro Elena,
Calder Philip C.,
Roche Helen M.
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202170003
Subject(s) - inflammasome , inflammation , oxidative stress , reactive oxygen species , tlr4 , chemistry , metabolism , glycolysis , receptor , biochemistry , biology , immunology
Mol. Nutr. Food Res . 2020, 65 , 1901071 DOI: 10.1002/mnfr.201901071 Dietary stressors, including saturated fats and sugars, generate endogenous stress signals that reconfigure host metabolism towards a glycolytic pro‐inflammatory state. Conversely, exercise, unsaturated fats, and dietary antioxidants direct metabolism towards oxidative phosphorylation and lower reactive oxygen species. This metabolic environment promotes resolution of inflammation. Cellular receptors like TLR4 and the NLRP3 inflammasome sense metabolic stressors and re‐program macrophages. This is reported by Elena De Marco Castro, Philip C. Calder, and Helen M. Roche in article 1901071.