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Anti‐Hyperglycemic Effects of Oils and Extracts Derived from Sea Buckthorn – A Comprehensive Analysis Utilizing In Vitro and In Vivo Models
Author(s) -
Ollinger Nicole,
Neuhauser Cathrina,
Schwarzinger Bettina,
Wallner Melanie,
Schwarzinger Clemens,
BlankLandeshammer Bernhard,
Hager Roland,
Sadova Nadiia,
Drotarova Ivana,
Mathmann Katrin,
Karamouzi Eugenia,
Panopoulos Panagiotis,
Rimbach Gerald,
Lüersen Kai,
Weghuber Julian,
Röhrl Clemens
Publication year - 2022
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202101133
Subject(s) - in vivo , in vitro , chemistry , biochemistry , pharmacology , biology , microbiology and biotechnology
Scope Sea buckthorn ( Hippophaes rhamnoides ) is capable of ameliorating disturbed glucose metabolism in animal models and human subjects. Here, the effect of sea buckthorn oil as well as of extracts of fruits, leaves, and press cake on postprandial glucose metabolism is systematically investigated. Methods and results Sea buckthorn did neither exert decisive effects in an in vitro model of intestinal glucose absorption nor did it alter insulin secretion. However, sea buckthorn stimulates GLUT4 translocation to the plasma membrane comparable to insulin, indicative of increased glucose clearance from the circulation. Isorhamnetin is identified in all sea buckthorn samples investigated and is biologically active in triggering GLUT4 cell surface localization. Consistently, sea buckthorn products lower circulating glucose by ≈10% in a chick embryo model. Moreover, sea buckthorn products fully revert hyperglycemia in the nematode Caenorhabditis elegans while they are ineffective in Drosophila melanogaster under euglycemic conditions. Conclusion These data indicate that edible sea buckthorn products as well as by‐products are promising resources for hypoglycemic nutrient supplements that increase cellular glucose clearance into target tissues.