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Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms
Author(s) -
TorresFuentes Cristina,
Suárez Manuel,
Aragonès Gerard,
Mulero Miquel,
ÁvilaRomán Javier,
ArolaArnal Anna,
Salvadó Maria Josepa,
Arola Lluís,
Bravo Francisca Isabel,
Muguerza Begoña
Publication year - 2022
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100990
Subject(s) - circadian rhythm , chronobiology , hyperlipidemia , rhythm , pharmacology , medicine , inflammation , physiology , endocrinology , diabetes mellitus
Cardiovascular diseases (CVD) are the leading cause of deaths worldwide and their prevalence is continuously increasing. Available treatments may present several side effects and therefore the development of new safer therapeutics is of interest. Phenolic compounds have shown several cardioprotective properties helpful in reducing different CVD risk factors such as inflammation, elevated blood pressure, hyperlipidemia, or endothelial dysfunction. These factors are significantly influenced by biological rhythms which are in fact emerging as key modulators of important metabolic and physiological processes. Thus, increased events of CVD have been observed under circadian rhythm disruption or in winter versus other seasons. These rhythms can also affect the functionality of phenolic compounds. Indeed, different effects have been observed depending on the administration time or under different photoperiods. Therefore, in this review the focus will be on the potential of phenolic compounds as therapeutics to prevent CVD via biological rhythm modulation.