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Altered Adiponectin Response in Older Women Following Dextrose and High‐Fat Dietary Challenges
Author(s) -
Herpich Catrin,
Kochlik Bastian,
Haß Ulrike,
Weber Daniela,
Grune Tilman,
Norman Kristina
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100487
Subject(s) - postprandial , adiponectin , medicine , endocrinology , fgf21 , ingestion , adiponectin receptor 1 , malondialdehyde , oxidative stress , insulin , insulin resistance , receptor , fibroblast growth factor
Scope Despite its beneficial properties, higher adiponectin concentrations are paradoxically associated with mortality in advanced age. Several mechanisms are being discussed. However, little is known about postprandial regulation of adiponectin in older adults. We assessed age‐specific differences of the adiponectin response to different test meals considering potential determinants. Methods and Results Older ( n = 20) and younger ( n = 22) women are randomized to a dextrose (DEX) or high‐fat (HF) dietary challenge. Postprandial adiponectin and fibroblast growth factor 21 (FGF21) concentrations are measured before and 60, 120, 240 min after ingestion. We assessed postprandial changes and group differences using linear mixed models controlled for possible determinants. In younger women, postprandial adiponectin remains stable after both test meals. In contrast, adiponectin increases following DEX and decreases after HF in older women, irrespective of control variables. Postprandial adiponectin is positively associated with malondialdehyde and inversely associated with interleukin‐6 following DEX and also negatively associated with metabolic parameters after both test meals. In older women, elevated postprandial FGF21 concentrations are associated with a higher adiponectin response (β = 30.7, 95% CI 10.6–50.8, p = 0.007). Conclusions Adiponectin response is associated with type of dietary challenge, age, and FGF21 response. Age‐group differences are partly attributable to metabolic parameters and oxidative stress.