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Matcha Green Tea Powder does not Prevent Diet‐Induced Arteriosclerosis in New Zealand White Rabbits Due to Impaired Reverse Cholesterol Transport
Author(s) -
Hunjadi Monika,
Sieder Claudia,
Beierfuß Anja,
Kremser Christian,
Moriggl Bernhard,
Welte René,
Kastner Christine,
Mern Demissew Shenegelegn,
Ritsch Andreas
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100371
Subject(s) - cholesterol , medicine , endocrinology , triglyceride , reverse cholesterol transport , chemistry , lipoprotein
Green tea is associated with decreased risk for cardiovascular disease and stroke. Matcha is a special kind of powdered green tea known for its use in the Japanese tea ceremony. Due to its influence on lipoprotein parameters, it has been postulated to exert antiatherogenic effects. This study investigates whether it modulates the high‐density lipoprotein (HDL) function and thereby influences the atherogenic process in an animal model with a strong influence on humans' situation. Methods and Results After a pretreatment phase based on a standard diet, 10 female New Zealand White (NZW) rabbits are fed a high‐fat diet for 20 weeks. The treatment group is additionally administered 1% matcha during the whole experiment. Long‐term matcha treatment leads to lowered HDL cholesterol, impaired cholesterol transport manifested by reduced in vitro cholesterol efflux capacity, reduced cholesteryl ester transfer protein (CETP)‐mediated cholesterol ester (CE) transfer between HDL and triglyceride‐rich particles, and reduced macrophage‐specific in vivo transfer, where ian increased absorption of cholesterol in the liver but a decreased secretion into bile is observed. Pulse wave velocity, assessed by nuclear magnetic resonance, is increased in matcha‐treated animals, and a similar trend is observed for atherosclerotic lesion formation. Conclusion Long‐term matcha green tea treatment of hypercholesterolemic rabbits cause impaired reverse cholesterol transport and increased vascular stiffness, and susceptibility for atherosclerotic lesion development.