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The Association Between Coffee Consumption and Nonalcoholic Fatty Liver Disease in the South Korean General Population
Author(s) -
Tan LiJuan,
Jung Hyein,
Kim SeongAh,
Shin Sangah
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100356
Subject(s) - nonalcoholic fatty liver disease , medicine , fatty liver , odds ratio , steatosis , hazard ratio , prospective cohort study , population , body mass index , lower risk , environmental health , disease , confidence interval
Scope To identify the cross‐sectional and prospective association between coffee consumption and nonalcoholic fatty liver disease (NAFLD) among South Korean adults. Methods and Results Participants are selected from the Health Examinees study. NAFLD is defined using three non‐invasive indexes: fatty liver index (FLI), hepatic steatosis index, and fibrosis‐4 calculator (FIB‐4). In the cross‐sectional analysis, higher habitual coffee consumption is associated with a lower risk for NAFLD, define using the FLI, (men, odds ratio [OR] 0.702; women, OR 0.810) compared with non‐consumers. Participants who consumed coffee with sugar and creamer also have a lower risk for NAFLD, defined using the FIB‐4, compared with non‐coffee‐consumers (men, OR 0.739; women, OR 0.807). A prospective analysis indicated that higher coffee consumption is associated with a lower incidence of NAFLD, defined using the FLI, in men (hazard ratio, 0.706). In both men and women, a lower FIB‐4 index score is associated with higher coffee consumption regardless of coffee type (all p ‐value <0.05). Conclusions Coffee consumption of >3 cups per day has a protective effect against the development of NAFLD to a certain extent, and a negative association is found between coffee consumed with sugar and creamer and the FIB‐4 index score in South Korean adults.