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Effect of Vitamin B2‐Deficient Diet on Hydroxyproline‐ or Obesity‐Induced Hyperoxaluria in Mice
Author(s) -
Uebanso Takashi,
Suyama Mai,
Shimohata Takaaki,
Mawatari Kazuaki,
Takahashi Akira
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100226
Subject(s) - primary hyperoxaluria , oxalate , hydroxyproline , medicine , endocrinology , endogeny , excretion , chemistry , urinary system , vitamin , kidney , urine , organic chemistry
Scope Hyperoxaluria is a major cause of kidney stone disease. Around half of the oxalate in mammals is supplied from the diet and the other half is endogenously synthesized from glyoxylate. Reduction of hepatic glycolate oxidase (GO) activity is one approach to reduce endogenous production of oxalate. However, there are currently few effective dietary approaches to reduce hepatic GO activity. Methods and Results In the present study, it is investigated whether restriction of dietary vitamin B2 (VB2) can reduce hepatic GO activity and oxalate excretion in mice with hyperoxaluria induce by hydroxyproline (Hyp) or obesity. It is found that VB2 restriction significantly reduces hepatic GO activity in both the Hyp‐ and obesity‐induced model of hyperoxaluria in mice. However, VB2 restriction reduces urinary oxalate excretion only in the Hyp‐treated mice and not the obese mice. This difference could be due to the contribution of endogenous oxalate production that manifests as increased hepatic GO activity in Hyp‐treated mice but not obese mice. Conclusion Together these results suggest that VB2 restriction could be a new dietary approach to improve hyperoxaluria when endogenous production of oxalate is increased.