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Safety and Efficacy of a Beverage Containing Lupine Protein Hydrolysates on the Immune, Oxidative and Lipid Status in Healthy Subjects: An Intervention Study (the Lupine‐1 Trial)
Author(s) -
CruzChamorro Ivan,
ÁlvarezSánchez Nuria,
ÁlvarezRíos Ana Isabel,
SantosSánchez Guillermo,
Pedroche Justo,
Millán Francisco,
Carrera Sánchez Cecilio,
FernándezPachón María Soledad,
MillánLinares María Carmen,
MartínezLópez Alicia,
Lardone Patricia Judith,
Bejarano Ignacio,
Guerrero Juan Miguel,
CarrilloVico Antonio
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100139
Subject(s) - cholesterol , immune system , lipid profile , ingestion , antioxidant , medicine , peripheral blood mononuclear cell , high density lipoprotein , oxidative stress , blood lipids , physiology , immunology , biology , biochemistry , in vitro
Scope We have previously demonstrated the anti‐inflammatory and antioxidant properties of in vitro administered Lupinus angustifolius protein hydrolysates (LPHs) on human peripheral blood mononuclear cells (PBMCs). This study aims to evaluate the safety and efficacy of a beverage containing LPHs (LPHb) on the immune, oxidative and metabolic status of healthy subjects. Methods and Results In this open‐label intervention, 33 participants daily ingest a LPHb containing 1 g LPHs for 28 days. Biochemical parameters are assayed in fasting peripheral blood and urine samples before, during (14 days) and after LPHb ingestion. Participants’ health status and the immune and antioxidant responses of PBMCs are also evaluated throughout the trial. The LPHb ingestion is safe and effective in both increasing the anti‐/pro‐inflammatory response of PBMCs and improving the cellular anti‐oxidant capacity. LPHb also reduces the low‐density lipoprotein‐cholesterol (LDL‐C)/high‐density lipoprotein‐cholesterol (HDL‐C) atherogenic index. LPHb effect is particularly beneficial on decreasing not only the LDL‐C/HDL‐C index but also serum total cholesterol levels in the male cohort that shows the highest baseline levels of well‐known cardiovascular risk factors. Conclusion This is the first study to show the pleiotropic actions of a lupine bioactive peptides‐based functional food on key steps of atherosclerosis including inflammation, oxidative stress, and cholesterol metabolism.