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A Novel Potent Sleep‐Promoting Effect of Turmeric: Turmeric Increases Non‐Rapid Eye Movement Sleep in Mice Via Histamine H 1 Receptor Blockade
Author(s) -
Um Min Young,
Yoon Minseok,
Lee Jaekwang,
Jung Jonghoon,
Cho Suengmok
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202100100
Subject(s) - histaminergic , pharmacology , non rapid eye movement sleep , insomnia , rapid eye movement sleep , agonist , sleep (system call) , medicine , diazepam , endocrinology , histamine , chemistry , receptor , neuroscience , electroencephalography , psychology , computer science , operating system
Scope Turmeric has a broad spectrum of biological properties; however, the sleep‐promoting effects of turmeric have not yet been reported. Thus, this study aims to investigate the effect of turmeric on sleep and the molecular mechanism underlying this effect. Methods and Results Pentobarbital‐induce sleep test and sleep‐wake profile assessment using recorded electroencephalography are used to evaluate the hypnotic effects of the turmeric extract (TE) compared to diazepam on sleep in mice. Additionally, the molecular mechanism of TE's sleep effect is investigated using ex vivo electrophysiological recordings from brain slices in histamine H 1 receptor (H 1 R) knockout mice. Oral administration of TE and diazepam significantly reduce sleep latency and increase non‐rapid eye movement sleep (NREMS) duration without delta activity in mice. Like doxepin, TE inhibits the H 1 R agonist (2‐pyridylethylamine dihydrochloride)‐induced increase in action potentials in the hypothalamic neurons. In animal tests using neurotransmitter agonists or antagonists, TE effect mimick H 1 R antagonistic effect of doxepin. Additionally, both reduce sleep latency and increase NREMS in wild‐type mice, although these effects are not observed in H 1 R knockout mice. Conclusion TE has a sleep‐promoting effect owing to reduction in sleep latency and enhancement of NREMS via H 1 R blockade; therefore, it could be useful in insomnia.