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Front Cover: Prenatal High‐Salt Diet–Induced Metabolic Disorders via Decreasing Peroxisome Proliferator–Activated Receptor Gamma Coactivator 1α in Adult Male Rat Offspring
Author(s) -
Liu Yanping,
Yang Chunli,
Feng Xueqin,
Qi Linglu,
Guo Jun,
Zhu Dan,
Thai Phung N.,
Zhang Yingying,
Zhang Pengjie,
Sun Miao,
Lv Juanxiu,
Zhang Lubo,
Xu Zhice,
Lu Xiyuan
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202070032
Subject(s) - offspring , endocrinology , medicine , fetus , glut4 , biology , peroxisome proliferator activated receptor , pregnancy , gestation , peroxisome , receptor , insulin resistance , insulin , genetics
Mol. Nutr. Food Res . 2020, 64 , 2000196 DOI: 10.1002/mnfr.202000196 Maternal high‐salt diet during gestation markedly down‐regulated the expression of PGC‐1α in skeletal muscle of adult offspring, which led to impaired mitochondrial function and reduced Glut4 levels, which ultimately contributed to metabolic disorders. These findings enhance the understanding of metabolic dysfunction development of fetal origins. This is reported by Yanping Liu, Chunli Yang, Xueqin Feng, Linglu Qi, Jun Guo, Dan Zhu, Phung N. Thai, Yingying Zhang, Pengjie Zhang, Miao Sun, Juanxiu Lv, Lubo Zhang, Zhice Xu, Xiyuan Lu in the article 2000196.