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Front Cover: Ameliorating Activity of Ishige okamurae on the Amyloid Beta–Induced Cognitive Deficits and Neurotoxicity through Regulating ERK, p38 MAPK, and JNK Signaling in Alzheimer's Disease–Like Mice Model
Author(s) -
Kwon Oh Yun,
Lee Seung Ho
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202070028
Subject(s) - neurotoxicity , p38 mitogen activated protein kinases , mapk/erk pathway , amyloid beta , kinase , protein kinase a , pharmacology , medicine , disease , alzheimer's disease , neuroscience , toxicity , biology , microbiology and biotechnology
Mol. Nutr. Food Res . 2020, 64 , 1901220 DOI: 10.1002/mnfr.201901220 By using an Alzheimer's disease (AD)‐like mice model, Oh Yun Kwon and Seung Ho Lee demonstrate that oral administration of Ishige okamurae extract (IOE) attenuates amyloid beta peptide–mediated cognitive deficits and neuronal toxicity through inhibition of abnormal activation of mitogen‐activated protein kinase (MAPK). The study, described in article 1901220, suggests that IOE could be developed as a potential anti‐AD agent.