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Front Cover: Procyanidin C1 Inhibits Melanoma Cell Growth by Activating 67‐kDa Laminin Receptor Signaling
Author(s) -
Bae Jaehoon,
Kumazoe Motofumi,
Murata Kyosuke,
Fujimura Yoshinori,
Tachibana Hirofumi
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202070017
Subject(s) - protein phosphatase 2 , phosphatase , proanthocyanidin , receptor , protein kinase a , kinase , signal transduction , microbiology and biotechnology , chemistry , biology , biochemistry , phosphorylation , polyphenol , antioxidant
Mol. Nutr. Food Res . 2020, 64 , 1900986 DOI: 10.1002/mnfr.201900986 In article 1900986, Hirofumi Tachibana and co‐workers identify a 67‐kDa laminin receptor (67LR) as a cell‐surface‐sensing receptor of Procyanidin C1 (PC1), which is found mainly in grape seeds, cacao beans, and apple peels. PC1 shows bioactivity by activating the protein kinase A (PKA)/protein phosphatase 2A (PP2A)/C‐kinase potentiated protein phosphatase‐1 inhibitor protein of 17 kDa (CPI17)/myosin regulatory light‐chain (MRLC)‐pathway through 67LR.