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Front Cover: Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S ‐Equol and Its Consequences for ERα Activation
Author(s) -
Wang Qianrui,
Spenkelink Bert,
Boonpawa Rungnapa,
Rietjens Ivonne M. C. M.,
Beekmann Karsten
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202070013
Subject(s) - equol , daidzein , metabolite , metabolism , chemistry , ingestion , food science , biochemistry , biology , endocrinology , genistein
Mol. Nutr. Food Res . 2020, 64 , 1900912 DOI: 10.1002/mnfr.201900912 In article 1900912, Qianrui Wang and co‐workers predict plasma concentrations of daidzein and its gut microbial metabolite, S ‐equol, following daidzein ingestion using a PBK model that includes a gut microbial compartment. In vitro anaerobic incubations of rat feces are optimized to derive kinetic parameters of gut microbial metabolism of daidzein to DHD, S ‐equol, and O ‐DMA, which are used as input for the PBK model.