Front Cover: Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to  S ‐Equol and Its Consequences for ERα Activation | Zendy

Wang Qianrui | Zendy; Spenkelink Bert | Zendy; Boonpawa Rungnapa | Zendy; Rietjens Ivonne M. C. M. | Zendy; Beekmann Karsten | Zendy

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Front Cover: Use of Physiologically Based Kinetic Modeling to Predict Rat Gut Microbial Metabolism of the Isoflavone Daidzein to S ‐Equol and Its Consequences for ERα Activation

Author(s) -

Wang Qianrui,

Spenkelink Bert,

Boonpawa Rungnapa,

Rietjens Ivonne M. C. M.,

Beekmann Karsten

Publication year - 2020

Publication title -

molecular nutrition and food research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.495

H-Index - 131

eISSN - 1613-4133

pISSN - 1613-4125

DOI - 10.1002/mnfr.202070013

Subject(s) - equol , daidzein , metabolite , metabolism , chemistry , ingestion , food science , biochemistry , biology , endocrinology , genistein

Mol. Nutr. Food Res . 2020, 64 , 1900912 DOI: 10.1002/mnfr.201900912 In article 1900912, Qianrui Wang and co‐workers predict plasma concentrations of daidzein and its gut microbial metabolite, S ‐equol, following daidzein ingestion using a PBK model that includes a gut microbial compartment. In vitro anaerobic incubations of rat feces are optimized to derive kinetic parameters of gut microbial metabolism of daidzein to DHD, S ‐equol, and O ‐DMA, which are used as input for the PBK model.

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