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Front Cover: Biotransformation of Piceatannol, a Dietary Resveratrol Derivative: Promises to Human Health
Author(s) -
Dai Yu,
Lim Jin Xuan,
Yeo Samuel Chao Ming,
Xiang Xiaoqiang,
Tan Kai Soo,
Fu Jia Hui,
Huang Lizhen,
Lin HaiShu
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202070005
Subject(s) - piceatannol , front cover , biotransformation , resveratrol , catechol , chemistry , biochemistry , enzyme , pharmacology , biology , cover (algebra) , mechanical engineering , engineering
Mol. Nutr. Food Res . 2020, 64 , 1900905 DOI: 10.1002/mnfr.201900905 In article number 1900905, Hai‐Shu Lin and co‐workers find that piceatannol is extensively converted to two pharmacologically active metabolites, rhapontigenin and isorhapontigenin, by catechol‐ O ‐methyltransferase. Moreover, piceatannol is identified as a substrate inhibitor of catechol‐ O ‐methyltransferase. This study also suggests that active metabolites and reversed metabolism of piceatannol contribute to its health‐promoting effects.