Premium
Front Cover: Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism
Author(s) -
Zhang Yang,
Bobe Gerd,
Revel Johana S.,
Rodrigues Richard R.,
Sharpton Thomas J.,
Fantacone Mary L.,
Raslan Kareem,
Miranda Cristobal L.,
Lowry Malcolm B.,
Blakemore Paul R.,
Morgun Andrey,
Shulzhenko Natalia,
Maier Claudia S.,
Stevens Jan F.,
Gombart Adrian F.
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202070003
Subject(s) - xanthohumol , gut flora , metabolic syndrome , metabolism , bile acid , obesity , chemistry , adipose tissue , endocrinology , medicine , biochemistry , pharmacology , biology , ecology , key (lock)
Mol. Nutr. Food Res . 2020, 64 , 1900789 DOI: 10.1002/mnfr.201900789 Hops‐derived xanthohumol (XN) and derivatives DXN and TXN reduce high‐fat diet (HFD)‐induced obesity and metabolic disorders in rodents. In article number 1900789, Adrian F. Gombart and co‐workers show that these compounds function as novel modulators of gut microbiota, reducing diversity and altering bile acid metabolism to ameliorate HFD‐induced obesity, adipose inflammation, and metabolic syndrome.