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Anti‐Obesity Effect of T. Chebula Fruit Extract on High Fat Diet Induced Obese Mice: A Possible Alternative Therapy
Author(s) -
Subramanian Gowtham,
Shanmugamprema Deepankumar,
Subramani Ramya,
Muthuswamy Karthi,
Ponnusamy Vinithra,
Tankay Kalpana,
Velusamy Thirunavukkarasu,
Krishnan Vasanth,
Subramaniam Selvakumar
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202001224
Subject(s) - lipogenesis , endocrinology , medicine , fatty acid synthase , chemistry , adipose tissue , carnitine , obesity , peroxisome proliferator activated receptor , tumor necrosis factor alpha , beta oxidation , fatty acid , pharmacology , biochemistry , receptor
Occurrence of obesity and its associated metabolic disorders continues to escalate. The present study evaluates the anti‐obesity effects of ethanolic fruit extract of Terminalia chebula (EETC) on high fat diet induced obese mice. The bioactive compounds present in the EETC is evaluated by Fourier‐transform infrared (FT‐IR), Gas chromatography‐mass spectrometry (GC‐MS), and Liquid chromatography‐mass spectrometry (LC‐MS) analysis. The effects of EETC on energy intake, glucose tolerance, and various biochemical parameters were analyzed using laboratory mice. Relative gene expression of Fatty acid synthase (FAS), Peroxisome proliferator‐activated receptors α (PPARα), Carnitine palmitoyltransferase‐1 (CPT‐1), Tumor necrosis factor alpha (TNF‐α) as well as Interleukin 6 (IL‐6) were analyzed in liver and adipose tissues. The findings reveal the hypolipidemic and anti‐obesity potential of EETC on high fat fed obese mice. EETC exerts its anti‐obesity effects by suppressing lipogenesis through reduction in lipogenic enzyme (FAS) expression, increased fatty acid oxidation via PPARα and CPT‐1 and by triggering the anti‐inflammatory responses. To our knowledge, this is the first report of the effect of EETC on PPARα and CPT‐1 in in vivo.