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Milk Polar Lipids Supplementation to Obese Rats During Pregnancy and Lactation Benefited Skeletal Outcomes of Male Offspring
Author(s) -
Han Lihua,
Du Min,
Ren Fazheng,
Mao Xueying
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202001208
Subject(s) - offspring , endocrinology , medicine , lactation , pregnancy , biology , weaning , insulin resistance , insulin , genetics
Scope Dietary intervention to obese dams during pregnancy and lactation period provides avenues for improving metabolic profiles of the offspring. In the current study, the effects of polar lipids‐enriched milk fat globule membrane (MFGM‐PL) supplementation to obese dams during pregnancy and lactation on the skeletal outcomes of male offspring are investigated. Methods and Results MFGM‐PL is supplemented to obese rats induced by high‐fat diet during pregnancy and lactation at a dose of 400 mg kg ‐1 body weight. Results show that maternal MFGM‐PL supplementation significantly ameliorates the stunted skeletal growth of male offspring at weaning. In adulthood offspring, maternal MFGM‐PL supplementation protects against high‐fat diet (HFD)‐induced bone microstructure degeneration and bone marrow adipocyte accumulation. Further investigation shows that maternal supplementation of MFGM‐PL significantly ameliorates insulin resistance and increases the mRNA expression of growth hormone releasing hormone (GHRH) in the hypothalamus of HFD offspring. The growth hormone (GH)/insulin‐like growth factor‐1 (IGF‐1) axis is subsequently enhanced in MFGM‐PL + HFD offspring, contributing to the beneficial skeletal outcomes. Conclusion The findings suggest that maternal MFGM‐PL supplementation of HFD dam during pregnancy and lactation shows desirable effects on fetal skeletal development, with lasting beneficial programming impacts on skeletal outcomes of offspring.