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Diallyl Trisulfide Prevents Obesity and Decreases miRNA‐335 Expression in Adipose Tissue in a Diet‐Induced Obesity Rat Model
Author(s) -
Miura Atsushi,
Ikeda Ayana,
Abe Marina,
Seo Kiki,
Watanabe Takahiro,
OzakiMasuzawa Yori,
Hosono Takashi,
Seki Taiichiro
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202001199
Subject(s) - diallyl trisulfide , lipogenesis , endocrinology , medicine , adipose tissue , obesity , diallyl disulfide , white adipose tissue , triglyceride , microrna , chemistry , biochemistry , apoptosis , cholesterol , gene
Scope Diallyl trisulfide (DATS), an organosulfur compound generates in crushed garlic, has various beneficial health effects. A growing body of evidence indicates that miRNAs are involved in the pathology of lifestyle diseases including obesity. The anti‐obesogenic effect of garlic is previously reported; however, the effects of DATS on obesity, and the relationship between garlic compounds and the involvement of miRNA remains unclear. Here, the anti‐obesogenic activity of DATS and the potential role of miRNA in a diet‐induced obesity rat model are investigated. Methods and Results Oral administration of DATS suppressed body and white adipose tissue (WAT) weight gain in rats fed a high‐fat diet compared with vehicle‐administered rats. DATS lowered the plasma and liver triglyceride levels in obese rats, and decreased lipogenic mRNA levels including those of Srebp1c, Fasn, and Scd1 in the liver. DATS also suppressed de novo lipogenesis in the liver. Transcriptomic analyses of miRNA and mRNA in the epididymal WAT of obese rats using microarrays revealed that DATS decreased miRNA‐335 expression and normalized the obesity‐related mRNA transcriptomic signatures in epididymal WAT. Conclusion The potent anti‐obesogenic effects of DATS and its possible mechanism of action was clearly demonstrated in this study.