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Metabolomic Changes after Coffee Consumption: New Paths on the Block
Author(s) -
Favari Claudia,
Righetti Laura,
Tassotti Michele,
Gethings Lee Andrew,
Martini Daniela,
Rosi Alice,
Antonini Monica,
Rubert Josep,
Manach Claudine,
Dei Cas Alessandra,
Bonadonna Riccardo,
Brighenti Furio,
Dall'Asta Chiara,
Mena Pedro,
Del Rio Daniele
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000875
Subject(s) - metabolomics , green coffee , crossover study , caffeine , coffea arabica , metabolic pathway , biology , microbiology and biotechnology , metabolism , food science , medicine , biochemistry , bioinformatics , endocrinology , botany , alternative medicine , pathology , placebo
Scope Several studies suggest that regular coffee consumption may help preventing chronic diseases, but the impact of daily intake and the contribution of coffee metabolites in disease prevention are still unclear. The present study aims at evaluating whether and how different patterns of coffee intake (one cup of espresso coffee/day, three cups of espresso coffee/day, and one cup of espresso coffee/day and two cocoa‐based products containing coffee two times per day) may impact endogenous molecular pathways. Methods and Results A three‐arm, randomized, crossover trial is performed in 21 healthy volunteers who consumed each treatment for one month. Urine samples are collected to perform untargeted metabolomics based on UHPLC‐IMS‐HRMS. A total of 153 discriminant metabolites are identified. Several molecular features are associated with coffee consumption, while others are linked with different metabolic pathways, such as phenylalanine, tyrosine, energy metabolism, steroid hormone biosynthesis, and arginine biosynthesis and metabolism. Conclusion This information has provided new insights into the metabolic routes by which coffee and coffee‐related metabolites may exert effects on human health.