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Antidepressant‐like Effects of Degraded Porphyran Isolated from Porphyra haitanensis
Author(s) -
Yi LiTao,
Zhang ManMan,
Cheng Jie,
Wan HuiQi,
Li ChengFu,
Zhu JiXiao,
Zhang QiuPing,
Liu Qing,
Xu GuangHui
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000869
Subject(s) - creb , neurogenesis , neuroinflammation , pharmacology , proinflammatory cytokine , dentate gyrus , neurotrophic factors , antidepressant , chemistry , hippocampal formation , hippocampus , medicine , biology , inflammation , microbiology and biotechnology , biochemistry , receptor , transcription factor , gene
Degraded porphyran is a bioactive polysaccharide extracted from Porphyra haitanensis ( P. haitanensis ). According to the previous studies, it produced anti‐inflammatory activity, but little is known about its effects on depression. Methods and Results As inflammation is one of the critical factors involved in the development of depression, this study aims to elucidate the potential antidepressant‐like effects of degraded porphyran. The results show that acute porphyran treatment decreased the immobility time in despair tests. In addition, subchronic porphyran administration reverses depressive‐like behaviors in lipopolysaccharide (LPS)‐treated mice. Meanwhile, porphyran inhibits NF‐κB/NLRP3 signaling, proinflammatory cytokine release, and microglial activation in the hippocampus. Moreover, chronic porphyran treatment activates hippocampal brain derived neurotrophic factor (BDNF)/TrkB/ERK/CREB signaling pathway in chronic unpredictable mild stress (CUMS) in mice. As a result, neurogenesis and spinogenesis are maintained. Conclusions The findings of the present study indicate that degraded porphyran intake provides a potential strategy for depression treatment, which is mediated by the inhibition of neuroinflammation and the enhancement of neurogenesis and spinogenesis in the central nervous systems.