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No Effect of Dietary Fish Oil Supplementation on the Recruitment of Brown and Brite Adipocytes in Mice or Humans under Thermoneutral Conditions
Author(s) -
Maurer Stefanie F.,
Dieckmann Sebastian,
Lund Jens,
Fromme Tobias,
Hess Anne Lundby,
Colson Cécilia,
Kjølbæk Louise,
Astrup Arne,
Gillum Matthew Paul,
Larsen Lesli Hingstrup,
Liebisch Gerhard,
Amri EzZoubir,
Klingenspor Martin
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000681
Subject(s) - thermogenesis , fish oil , brown adipose tissue , endocrinology , medicine , adipose tissue , polyunsaturated fatty acid , adipocyte , biology , chemistry , food science , fish <actinopterygii> , fatty acid , biochemistry , fishery
Scope Brown and brite adipocytes within the mammalian adipose organ provide non‐shivering thermogenesis and thus, have an exceptional capacity to dissipate chemical energy as heat. Polyunsaturated fatty acids (PUFA) of the n3‐series, abundant in fish oil, have been repeatedly demonstrated to enhance the recruitment of thermogenic capacity in these cells, consequently affecting body adiposity and glucose tolerance. These effects are scrutinized in mice housed in a thermoneutral environment and in a human dietary intervention trial. Methods and results Mice are housed in a thermoneutral environment eliminating the superimposing effect of mild cold‐exposure on thermogenic adipocyte recruitment. Dietary fish oil supplementation in two different inbred mouse strains neither affects body mass trajectory nor enhances the recruitment of brown and brite adipocytes, both in the presence and absence of a β3‐adrenoreceptor agonist imitating the effect of cold‐exposure on adipocytes. In line with these findings, dietary fish oil supplementation of persons with overweight or obesity fails to recruit thermogenic adipocytes in subcutaneous adipose tissue. Conclusion Thus, the authors' data question the hypothesized potential of n3‐PUFA as modulators of adipocyte‐based thermogenesis and energy balance regulation.