Premium
Maternal Fructose Intake Increases Liver H 2 S Synthesis but Exarcebates its Fructose‐Induced Decrease in Female Progeny
Author(s) -
Fauste Elena,
Rodrigo Silvia,
Aguirre Rodrigo,
Donis Cristina,
Rodríguez Lourdes,
ÁlvarezMillán Juan J.,
Panadero María I.,
Otero Paola,
Bocos Carlos
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000628
Subject(s) - fructose , endocrinology , medicine , gestation , metabolism , homocysteine , chemistry , biology , pregnancy , biochemistry , genetics
Scope Fructose intake from added sugars correlates with the epidemic rise in metabolic syndrome and cardiovascular diseases (CVD). However, consumption of beverages containing fructose is allowed during gestation. Homocysteine (Hcy) is a well‐known risk factor for CVD while hydrogen sulfide (H 2 S), a product of its metabolism, has been proved to exert opposite effects to Hcy. Methods and results First, it is investigated whether maternal fructose intake produces subsequent changes in Hcy metabolism and H 2 S synthesis of the progeny. Carbohydrates are supplied to pregnant rats in drinking water (10% wt/vol) throughout gestation. Adult female descendants from fructose‐fed, control or glucose‐fed mothers are studied. Females from fructose‐fed mothers have elevated homocysteinemia, hepatic H 2 S production, cystathionine γ‐lyase (CSE) (the key enzyme in H 2 S synthesis) expression and plasma H 2 S, versus the other two groups. Second, it is studied how adult female progeny from control (C/F), fructose‐ (F/F), and glucose‐fed (G/F) mothers responded to liquid fructose and compared them to the control group (C/C). Interestingly, hepatic CSE expression and H 2 S synthesis are diminished by fructose intake, this effect being more pronounced in F/F females. Conclusion Maternal fructose intake produces a fetal programming that increases hepatic H 2 S production and, in contrast, exacerbates its fructose‐induced drop in female progeny.