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Gymnaster Koraiensis Extract Alleviated Metabolic Syndrome Symptoms and Stimulated UCP1‐Independent Energy Consumption via AMPK Activation in White Adipose Tissue
Author(s) -
Jung Da Seul,
Son YangJu,
Shin Ji Min,
Won Hyo Jun,
Le Tam Thi,
Jung Sang Hoon,
Lee ChangHo,
Nho Chu Won
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000490
Subject(s) - insulin resistance , metabolic syndrome , ampk , endocrinology , white adipose tissue , medicine , hyperlipidemia , oxidative stress , adipose tissue , orlistat , weight loss , insulin , diabetes mellitus , protein kinase a , obesity , chemistry , kinase , biochemistry
Scope Metabolic syndrome and obesity are rising worldwide concerns that are accompanied by adverse health consequences. Here, it is hypothesized that the ethanol extract from Gymnaster koraiensis (GK), an edible Korean plant known for its anti‐cancer and hepatoprotective properties, could attenuate metabolic syndrome‐related symptoms in high‐fat dietary‐induced obese (DIO) mice. Methods and Results Administration of 100 mg kg −1 GK extract to DIO mice effectively reduces body and white adipose tissue (WAT) weight. It also reduces cardiovascular disease risk and improves insulin resistance by lowering the fasting blood glucose levels and mitigating oxidative stress and inflammation. Moreover, supplementation with GK causes elevated energy expenditure in WAT by increasing the mitochondrial oxidative capacity and lipid catabolism through upregulated adenosine monophosphate‐activated protein kinase (AMPK) signaling. Orlistat is used as a positive control drug due to its widespread use in previous studies. It is found that GK extract causes weight loss, similar to Orlistat, and it additionally shows unique functions, such as upregulation of energy consumption in WAT. Conclusion GK extract treatment prominently reduces obesity and its associated metabolic complications, such as hyperlipidemia, hyperglycemia, and insulin resistance. Hence, It can be used as a promising multi‐target functional food that can improve metabolic syndrome‐related symptoms.