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Food Structure Modulates the Bioavailability of Triglycerides and Vitamin D, and Partly That of Lutein: A Randomized Trial with a Crossover Design in Adults
Author(s) -
Gleize Béatrice,
Hiolle Ma,
Meunier Nathalie,
Pereira Bruno,
Richard Ruddy,
SavaryAuzeloux Isabelle,
Buffière Caroline,
Peyron MarieAgnès,
Halimi Charlotte,
CarisVeyrat Catherine,
Nau Françoise,
Reboul Emmanuelle
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000228
Subject(s) - bioavailability , postprandial , food science , triglyceride , lutein , micronutrient , chylomicron , crossover study , vitamin , chemistry , population , medicine , cholesterol , carotenoid , biochemistry , lipoprotein , pharmacology , very low density lipoprotein , alternative medicine , environmental health , organic chemistry , pathology , insulin , placebo
Scope The specific effect of the food matrix structure on fat‐soluble micronutrient bioavailability is only partly understood. Evaluating fat‐soluble micronutrient bioavailability after consumption of foods displaying similar composition but different structure is aimed at. Methods and results Twelve healthy subjects are enrolled in a randomized, open label, crossover postprandial trial. Four different model foods are tested: custard, pudding, sponge cake, and biscuit. Vitamin D 3 , lutein, and triglyceride chylomicron responses, evaluated as postprandial areas under the curve, are then assayed. Custard triglyceride response is higher than pudding and biscuit responses (up to +122.7%, p < 0.0001). Sponge cake vitamin D 3 response is higher than biscuit response (+26.6%, p = 0.047). No difference between the model foods are observed regarding lutein responses. Triglyceride responses peak at 3 h for all conditions, while vitamin D 3 and lutein peaks are delayed by 1 h with the biscuit matrix compared to other model foods. Conclusion Food structure can significantly impact on triglyceride and vitamin D 3 bioavailability in terms of absorbed amounts and/or maximum absorption time. The data highlight positive correlations between triglyceride, vitamin D, and lutein nutrient responses. These results are of particular interest to develop functional foods for population subgroups such as the elderly.