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Microbial Products and Metabolites Contributing to Alcohol‐Related Liver Disease
Author(s) -
Gao Bei,
Emami Atoosa,
Nath Shilpa,
Schnabl Bernd
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.202000023
Subject(s) - liver disease , butyrate , cytolysin , alcohol , gut flora , alcoholic liver disease , fatty liver , microbiome , microbiology and biotechnology , biochemistry , biology , chemistry , disease , medicine , cirrhosis , bioinformatics , gastroenterology , fermentation , virulence , gene
As a serious public health concern, alcohol‐related liver disease is associated with dysregulations in the intestinal barrier function and the gut microbiota. The liver and gut communicate via the gut–liver axis, through which microbial products and metabolites translocate to the liver. Here, the current knowledge of various microbial products and metabolites which contribute to the alcohol‐related liver diseases, including bile acids, indole‐3‐acetic acid, butyrate, long‐chain fatty acids, endotoxin, cytolysin, β‐glucan, and candidalysin is reviewed. Some of these might serve as therapeutic targets for alcohol‐related liver disease.