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Front cover: Antihypertensive Potential of Coenzyme Q10 via Free Radical Scavenging and Enhanced Akt‐nNOS Signaling in the Nucleus Tractus Solitarii in Rats
Author(s) -
Chen HsinHung,
Yeh TungChen,
Cheng PeiWen,
Ho WenYu,
Ho ChiuYi,
Lai ChiCheng,
Sun GwoChing,
Tseng ChingJiunn
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201970015
Subject(s) - coenzyme q10 , sod2 , oxidative stress , chemistry , protein kinase b , nadph oxidase , phosphorylation , stimulation , endocrinology , medicine , oxidative phosphorylation , signal transduction , pharmacology , superoxide dismutase , biochemistry
Mol. Nutr. Food Res . 2019, 63 , 1801042 DOI: 10.1002/mnfr.201801042 Coenzyme Q10 (CoQ10) has therapeutic benefits for oxidative stress and hypertension. Fructose might mediate this process via the overexpression of superoxide in the nucleus tractus solitarii (NTS), stimulation of NADPH oxidase activation, and the phosphorylation of p‐p38. However, CoQ10 mediates insulin downstream signaling in the NTS by 10% fructose intake via the phosphorylation of Akt S473 and nNOS S1416 and improves neurogenic hypertension via the inhibition of NADPH oxidases and increased SOD2 expression in the NTS.