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Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study
Author(s) -
GutierrezMariscal Francisco M.,
Cardelo Magdalena P.,
la Cruz Silvia,
AlcalaDiaz Juan F.,
RonceroRamos Irene,
Guler Ipek,
ValsDelgado Cristina,
LópezMoreno Alejandro,
Luque Raul M.,
DelgadoLista Javier,
PerezMartinez Pablo,
YuberoSerrano Elena M.,
LopezMiranda Jose
Publication year - 2021
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201901290
Subject(s) - mediterranean diet , medicine , glycation , diabetes mellitus , type 2 diabetes , type 2 diabetes mellitus , disease , endocrinology , proportional hazards model , coronary heart disease , gastroenterology , physiology
Scope It is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets. Methods and Results Patients from CORDIOPREV study, all with previous cardiovascular events, with T2DM at the beginning of the study are included. Patients are randomized to a Mediterranean or a low‐fat diet for five years. No different diabetes remission rates are found among diets. Serum methylglioxal (MG) and carboximethyllysine (CML), levels dietary AGE, as well as gene expression of AGER1 and RAGE are measured. Serum MG decreases only after the consumption of the Mediterranean diet. Moreover, a COX regression analysis shows that each SD decrease in the MG, occurring after the Mediterranean diet, increases the probability of T2DM remission with HR:2.56(1.02–6.25) and p = 0.046 and each SD increase in disposition index at baseline increases the probability of remission with HR:1.94(1.32–2.87) and p = 0.001. Conclusions It is demonstrated that the reduction of serum AGEs levels and the modulation of its metabolism, occurring after the consumption of a Mediterranean diet, might be involved in the molecular mechanism underlying the T2DM remission of newly diagnosed patients with coronary heart disease.