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Soy and Isoflavone Consumption and Multiple Health Outcomes: Umbrella Review of Systematic Reviews and Meta‐Analyses of Observational Studies and Randomized Trials in Humans
Author(s) -
Li Ni,
Wu Xiaoting,
Zhuang Wen,
Xia Lin,
Chen Yi,
Zhao Rui,
Yi Mengshi,
Wan Qianyi,
Du Liang,
Zhou Yong
Publication year - 2020
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201900751
Subject(s) - observational study , randomized controlled trial , medicine , meta analysis , systematic review , women's health initiative , environmental health , medline , biology , biochemistry
Scope To assess the existing evidence of associations between consumption of soy and isoflavone and multiple health outcomes. Methods and results This is an umbrella review of meta‐analyses and systematic reviews of randomized trials and observational studies in humans. 114 Meta‐analyses and systematic reviews are identified with 43 unique outcomes. Soy and isoflavone consumption seems more beneficial than harmful for a series of health outcomes. Beneficial associations are identified for cancers, cardiovascular disease, gynecological, metabolic, musculoskeletal, endocrine, neurological, and renal outcomes, particularly in perimenopausal women. Harmful association is only found for gastric cancer (RR: 1.17, 95% CI: 1.02–1.36) for high intake of miso soup (1–5 cups per day) in male. Conclusion Generally, soy and isoflavone consumption is more beneficial than harmful. The results herein support promoting soy intake as part of a healthy diet. Randomized controlled trials are necessary to confirm this finding.