Premium
Goat Milk Consumption Ameliorates Abnormalities in Glucose Metabolism and Enhances Hepatic and Skeletal Muscle AMP‐Activated Protein Kinase Activation in Rats Fed with High‐Fat Diets
Author(s) -
Liu Wei,
Sun Han,
Zhou Yalin,
Li Yong,
Qin Yong,
Li Ruijun,
Chen Yuhan,
Yu Lanlan,
Zhao Mengya,
Zhang Wei,
Xu Yajun
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201900703
Subject(s) - medicine , endocrinology , ampk , amp activated protein kinase , skeletal muscle , glucokinase , carbohydrate metabolism , protein kinase a , insulin , biology , kinase , biochemistry
Scope Diabetes endangers health and causes serious economic impediment. The aim of this study is to identify the effects of goat milk consumption on glucose metabolism of rats with high‐fat (HF) diet. Methods and results Sixty male Sprague Dawley rats are divided into five groups and fed with different diets for 24 weeks: goat‐milk‐based HF diet (GHF group; goat milk powder+HF diet), cow‐milk‐based HF diet (CHF group; cow milk powder+HF diet), HF diet, HF diet plus acarbose (HF+A group; acarbose+HF diet), and chow diet (CD group). Fasting glucose in GHF‐fed rats are lower than HF‐fed rats on weeks 16 and 20. GHF‐fed rats display improved insulin sensitivity in oral glucose and insulin tolerance tests. Compared with HF‐fed rats, glycated hemoglobin and triglycerides in GHF‐fed rats are lower and high‐density lipoprotein level is higher. AMP‐activated protein kinase activation (AMPK) in the liver and skeletal muscle is higher in GHF rats than HF rats. Phosphoenolpyruvate carboxykinase and glucose 6‐phosphatase protein levels in the liver are lower and hexokinase 2 protein level in the skeletal muscle is higher in GHF rats compared with HF rats. Conclusion Goat milk consumption can ameliorate abnormalities in glucose metabolism, and AMPK pathway in the liver and skeletal muscle plays an important role in the process.