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The Contribution of Lipids to the Interindividual Response of Vitamin K Biomarkers to Vitamin K Supplementation
Author(s) -
Kelly Jennifer M.,
Ordovas Jose M.,
Matuszek Gregory,
Smith Caren E.,
Huggins Gordon S.,
Dashti Hassan S.,
Ichikawa Reiko,
Booth Sarah L.
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201900399
Subject(s) - medicine , endocrinology , vitamin k , cholesterol , vitamin , biology , chemistry
Scope A better understanding of factors contributing to interindividual variability in biomarkers of vitamin K can enhance the understanding of the equivocal role of vitamin K in cardiovascular disease. Based on the known biology of phylloquinone, the major form of vitamin K, it is hypothesized that plasma lipids contribute to the variable response of biomarkers of vitamin K metabolism to phylloquinone supplementation. Methods and results The association of plasma lipids and 27 lipid‐related genetic variants with the response of biomarkers of vitamin K metabolism is examined in a secondary analysis of data from a 3‐year phylloquinone supplementation trial in men ( n = 66) and women ( n = 85). Year 3 plasma triglycerides (TG), but not total cholesterol, LDL‐cholesterol, or HDL‐cholesterol, are associated with the plasma phylloquinone response (men: β = 1.01, p < 0.001, R 2 = 0.34; women: β = 0.61, p = 0.008, R 2 = 0.11; sex interaction p = 0.077). Four variants and the TG‐weighted genetic risk score are associated with the plasma phylloquinone response in men only. Plasma lipids are not associated with changes in biomarkers of vitamin K function (undercarboxylated osteocalcin and matrix gla protein) in either sex. Conclusion Plasma TG are an important determinant of the interindividual response of plasma phylloquinone to phylloquinone supplementation, but changes in biomarkers of vitamin K carboxylation are not influenced by lipids.