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Impact of Weight Loss Strategies on Obesity‐Induced DNA Damage
Author(s) -
Setayesh Tahereh,
Mišík Miroslav,
Langie Sabine A. S.,
Godschalk Roger,
Waldherr Monika,
Bauer Thomas,
Leitner Sabine,
Bichler Christoph,
Prager Gerhard,
Krupitza Georg,
Haslberger Alexander,
Knasmüller Siegfried
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201900045
Subject(s) - dna damage , weight loss , obesity , endocrinology , medicine , overweight , comet assay , oxidative damage , biology , physiology , oxidative stress , dna , genetics
Scope Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material. Methods and Results Overweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage (“comet” formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses indicate that the reduction of DNA damage is associated with a decrease of pro‐inflammatory cytokines and lower insulin levels. Conclusion The study indicates that weight loss may prevent obesity‐associated adverse health effects due to reduction of overall DNA damage.