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Front cover: Integrated Remodeling of Gut–Liver Metabolism Induced by Moderate Protein Restriction Contributes to Improvement of Insulin Sensitivity
Author(s) -
Zhang Xin,
Qiu Kai,
Wang Liqi,
Xu Doudou,
Yin Jingdong
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201870088
Subject(s) - insulin , insulin sensitivity , metabolism , digestion (alchemy) , medicine , carbohydrate metabolism , metabolic pathway , front cover , endocrinology , biology , chemistry , biochemistry , insulin resistance , cover (algebra) , chromatography , mechanical engineering , engineering
Mol. Nutr. Food Res. 2018, 62 , 1800637 DOI: 10.1002/mnfr.201800637 In article number 1800637 , Jingdong Yin and co‐workers found that moderate protein restriction (PR) could improve insulin sensitivity in a pig model. Upon moderate PR, remodeling of gut‐liver metabolism was evidenced via multi‐omics analysis, including the enhanced protein digestion and absorption pathway in intestinal mucosa, modified concentrations of key metabolites in portal venous plasma, and improved insulin signaling pathways in the liver.