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Front cover: Diet during Pregnancy is Implicated in the Regulation of Hypothalamic RNA Methylation and Risk of Obesity in Offspring
Author(s) -
Kaspi Antony,
Khurana Ishant,
Ziemann Mark,
Connor Timothy,
Spolding Briana,
Zimmet Paul,
Walder Ken,
ElOsta Assam
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201870074
Subject(s) - offspring , epigenetics , dna methylation , biology , obesity , methylation , rna , endocrinology , appetite , medicine , hypothalamus , gene , pregnancy , rna methylation , genetics , gene expression , methyltransferase
Mol. Nutr. Food Res. 2018, 62 , 1800134 DOI: 10.1002/mnfr.201800134 Parental diet restriction regulates hypothalamic DNA cytosine methylation (5mC) and RNA adenosine methylation (m6A) and the risk of obesity in offspring. Parental diet alters hypothalamic appetite signals that coordinate epigenetic changes regulating the expression of genes implicated in obesity. Further details about this study can be found in article number 1800134 by Assam El‐Osta and co‐workers.