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Front cover: Butyrate Inhibits Indices of Colorectal Carcinogenesis via Enhancing α‐Ketoglutarate‐Dependent DNA Demethylation of Mismatch Repair Genes
Author(s) -
Sun Xiaofei,
Zhu MeiJun
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201870066
Subject(s) - butyrate , histone , microbiology and biotechnology , dna demethylation , acetylation , dna , dna methylation , biology , proliferating cell nuclear antigen , dna repair , carcinogenesis , dna mismatch repair , gene , chemistry , biochemistry , gene expression , fermentation
Mol. Nutr. Food Res. 2018, 62 , 1700932 DOI: 10.1002/mnfr.201700932 Butyrate, a gut microbiota metabolite, promotes histone acetylation and DNA demethylation in the promoter of DNA mismatch repair (MMR) gene in colorectal carcinoma cells, a process dependent on isocitrate dehydrogenase‐1 and α‐ketoglutarate. The immunofluorescence staining of PCNA, a marker of proliferating cells, is suppressed by butyrate at a physiologically relevant concentration in human colonic lumen. Further details can be found in article number 1700932 by Xiaofei Sun and Mei‐Jun Zhu.