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Back Cover: Aromatic‐Turmerone Attenuates LPS‐Induced Neuroinflammation and Consequent Memory Impairment by Targeting TLR4‐Dependent Signaling Pathway
Author(s) -
Chen Min,
Chang Yuanyuan,
Huang Shun,
Xiao Lihang,
Zhou Wei,
Zhang Lanyue,
Li Chun,
Zhou Renping,
Tang Jian,
Lin Li,
Du Zhiyun,
Zhang Kun
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201870023
Subject(s) - tlr4 , neuroinflammation , microglia , lipopolysaccharide , toll like receptor , chemistry , pharmacology , signal transduction , in vitro , receptor , inflammation , microbiology and biotechnology , medicine , immunology , innate immune system , biochemistry , biology
Mol. Nutr. Food Res. 2018, 62 , 1700281 DOI: 10.1002/mnfr.201700281 Oral administration of aromatic‐turmerone could reverse lipopolysaccharide (LPS)‐induced memory disturbance and normalize glucose intake and metabolism in the brains of mice. Moreover, aromatic‐turmerone significantly limits brain damage by inhibiting the activation of microglia and the generation of inflammatory cytokines. Further in vitro study reveals that aromatic‐turmerone‐targeted Toll‐like receptor 4 (TLR4) mediates downstream signaling and lowers the release of inflammatory mediators.