Premium
Front cover: Effects of a Grapevine Shoot Extract Containing Resveratrol and Resveratrol Oligomers on Intestinal Adenoma Development in Mice: In Vitro and In Vivo Studies
Author(s) -
Empl Michael T.,
Cai Hong,
Wang Shan,
Junginger Johannes,
Kostka Tina,
HewickerTrautwein Marion,
Brown Karen,
Gescher Andreas J.,
Steinberg Pablo
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201870021
Subject(s) - resveratrol , in vivo , in vitro , apoptosis , front cover , shoot , cell growth , biology , chemistry , biochemistry , botany , genetics , cover (algebra) , mechanical engineering , engineering
Mol. Nutr. Food Res. 2018, 62 , 1700450 DOI: 10.1002/mnfr.201700450 A grapevine shoot extract, which contains resveratrol as well as resveratrol oligomers, significantly reduces intestinal adenoma number in male Apc Min mice fed a high‐fat diet. In addition, the extract as well as some of its isolated ingredients inhibit the growth of adenoma‐derived APC10.1 cells in vitro by inducing cell cycle arrest, senescence, and apoptosis.