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Back Cover: Regulation of Hedgehog Signaling in Cancer by Natural and Dietary Compounds
Author(s) -
Bao Cheng,
Kramata Pavel,
Lee Hong Jin,
Suh Nanjoo
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201870015
Subject(s) - smoothened , gli1 , patched , hedgehog , hedgehog signaling pathway , transcription factor , signal transduction , biology , ptch1 , microbiology and biotechnology , medicine , chemistry , cancer research , endocrinology , biochemistry , gene
Mol. Nutr. Food Res. 2018, 62 , 1700621. DOI: 10.1002/mnfr.201700621 Aberrant Hh signaling can be regulated directly or indirectly by natural and dietary sources. Key Hh signaling mediators include Ptch, Smo, Gli and SuFu. In the presence of Hh ligands (HhN), the receptor Patched (Ptch) releases Smoothened (Smo) receptor which results in the activation of transcription factor Gli (Gli‐A) to increase the expression of genes GLI1, CCND1, SNAI1, VEGF, BMP4 and others.