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Jamun ( Eugenia jambolana Lam.) Fruit Extract Prevents Obesity by Modulating the Gut Microbiome in High‐Fat‐Diet‐Fed Mice
Author(s) -
Xu Jialin,
Liu Tingting,
Li Yuanyuan,
Liu Wei,
Ding Zhanjun,
Ma Hang,
Seeram Navindra P.,
Mu Yu,
Huang Xueshi,
Li Liya
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201801307
Subject(s) - gut flora , firmicutes , obesity , bacteroidetes , dysbiosis , biology , steatosis , insulin resistance , food science , microbiome , medicine , endocrinology , biochemistry , bioinformatics , 16s ribosomal rna , gene
Scope Published data support that gut microbiota play an important role in the pathological process of obesity and related metabolic disorders. In the current study, it is investigated whether a standardized extract from Jamun ( Eugenia jambolana ), a widely consumed tropical fruit, could alleviate obesity and alter gut microbial community in high‐fat diet (HFD)‐fed mice. Methods and results C57BL/6 mice are fed either a standard diet (SD) or HFD with or without Jamun fruit extract (JFE; 100 mg kg −1 day −1 ) by oral gavage for 8 weeks. JFE supplementation significantly alleviated diet‐induced obesity, insulin resistance, and liver steatosis. JFE supplementation also improved HFD‐induced gut dysbiosis by restoring the ratio of Firmicutes to Bacteroidetes as revealed by 16S rDNA analyses. The relative abundance of certain genera, as well as levels and proportion of intestinal‐derived short‐chain fatty acids are improved in JFE‐treated mice in comparison to the HFD‐fed control group. Conclusion These promising data show the potential association between gut microbiota modulation and metabolism improvement of the JFE administration, and support the utilization and further investigation of Jamun fruit as a dietary intervention strategy for the prevention of obesity and related metabolic disorders.