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Abundance of Probiotics and Butyrate‐Production Microbiome Manages Constipation via Short‐Chain Fatty Acids Production and Hormones Secretion
Author(s) -
Zhuang Min,
Shang Wenting,
Ma Qiuchen,
Strappe Padraig,
Zhou Zhongkai
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201801187
Subject(s) - butyrate , gut flora , hormone , roseburia , secretion , constipation , microbiome , biology , medicine , endocrinology , bacteria , immunology , biochemistry , lactobacillus , bioinformatics , genetics , fermentation
Scope The characteristics of gut microbiota and host metabolism are hypothesized to be associated with constipation status, but the regulation mechanism is not fully understood. Thus, the current study investigates the effect of constipation symptoms on gut functionality following the modulation of gut microbiota and metabolites via dietary fiber intervention. Methods and results Constipation causes a significantly reduced short‐chain fatty acids (SCFAs) production and a higher level of iso‐butyrate. The feces of constipated people are characterized with inhibited Faecalibacterium , Ruminococcaceae and Roseburia abundance. Desulfovibrionaceae is identified to be an important endotoxin producer in constipated patients, and a butyrate‐enriched SCFAs profile achieved by dietary fiber supplement accelerates gastrointestinal transit and increases the thickness of the mucosal layer, possibly through triggering the secretion of colonic hormones and enhancing the expression of tight junction proteins for maintaining intestinal barrier integrity. More importantly, an interacting regulatory mechanism among SCFAs, in particular butyrate and propionate, may be involved in signaling between the microbiome and host cells in the colon. Conclusion Gut microbiota, characterized with enriched butyrate‐producing and depressed Desulfovibrionaceae bacteria, attenuates constipation symptoms through promoting intestinal hormones secretion and maintaining gut barrier integrity.