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Chemopreventive Effects of Whole Cranberry ( Vaccinium macrocarpon ) on Colitis‐Associated Colon Tumorigenesis
Author(s) -
Wu Xian,
Song Mingyue,
Cai Xiaokun,
Neto Catherine,
Tata Anuradha,
Han Yanhui,
Wang Qi,
Tang Zhonghai,
Xiao Hang
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201800942
Subject(s) - azoxymethane , carcinogenesis , colitis , colorectal cancer , cancer research , apoptosis , inflammation , medicine , biology , immunology , cancer , biochemistry
Scope There are growing interests in using a whole‐food‐based approach to prevent chronic diseases due to potential synergistic interactions among different bioactive components within the whole foods. North American cranberry ( Vaccinium macrocarpon ), a polyphenol‐rich fruit, has been shown to exert multiple beneficial health effects. Methods and results For the first time, the protective effects of whole cranberry powder (WCP) are determined against colitis‐associated mouse colon tumorigenesis induced by azoxymethane (AOM) and dextran sulfate sodium (DSS). The results show that dietary administration of WCP (1.5%, w/w in the diet) significantly suppresses colon tumorigenesis as indicated by the reduced tumor incidence, multiplicity, burden, and average tumor size in WCP‐fed mice compared to the positive control mice. Both gene and protein expression levels of pro‐inflammatory cytokines IL‐1β, IL‐6, and TNF‐α are markedly attenuated by WCP treatment in the colon of AOM/DSS‐treated mice. Moreover, WCP profoundly modulates multiple signaling pathways/proteins related to inflammation, cell proliferation, apoptosis, angiogenesis, and metastasis in the colon, which is closely associated with the inhibitory effects of WCP on colon tumorigenesis. Conclusion Overall, the results demonstrate chemopreventive effects of WCP on colon tumorigenesis in mice, providing a scientific basis for using the whole cranberry as a functional food to promote colon health in humans.