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Premium Body Mass Index as a Determinant of Systemic Exposure to Gallotannin Metabolites during 6‐Week Consumption of Mango ( Mangifera indica L.) and Modulation of Intestinal Microbiota in Lean and Obese Individuals
Author(s)
Barnes Ryan C.,
Kim Hyemee,
Fang Chuo,
Bennett William,
Nemec Matthew,
Sirven Maritza A.,
Suchodolski Jan S.,
Deutz Nicolaas,
Britton Robert A.,
MertensTalcott Susanne U.,
Talcott Stephen T.
Publication year2019
Publication title
molecular nutrition and food research
Resource typeJournals
PublisherWiley-Blackwell
Scope This human clinical pilot trial investigated pharmacokinetics of gallotannin‐metabolites and modulation of intestinal microbiota in healthy lean and obese individuals after 6 weeks of daily mango consumption. Methods and results Participants are divided into three groups: Lean Mango (LM: n = 12; BMI = 22.9 kg m −2 ), Obese Mango (OM: n = 9; BMI = 34.6 kg m −2 ), and Lean Control (LC: n = 11; BMI = 22.1 kg m −2 ). LM and OM consumed 400 g of mango per day for 6 weeks. LC consumed mango only on Days 0 and 42. After 6 weeks, LM experienced increased systemic exposure (AUC 0–8h ) to gallotannin‐metabolites, 1.4‐fold ( p = 0.043). The greatest increase is 4‐ O ‐methyl‐gallic acid, 3.3‐fold ( p = 0.0026). Cumulative urinary excretion of gallotannin‐metabolites significantly increased in LM and OM, but not LC. For OM, qPCR data show increased levels of tannase‐producing Lactococcus lactis and decreased levels of Clostridium leptum and Bacteroides thetaiotaomicron , bacteria associated with obesity. LM experienced an increased trend of fecal levels of butyric (1.3‐fold; p = 0.09) and valeric acids (1.5‐fold; p = 0.056). Plasma endotoxins showed a decreased trend in LM and OM. Conclusion Continuous mango intake significantly increased systemic exposure to gallotannin‐ metabolites and induced an increased trend for fecal short‐chain fatty acids in lean but not obese individuals. This pharmacokinetic discrepancy may result in BMI‐associated reduced gallotannin‐derived health benefits.
Subject(s)biology , chemistry , feces , food science , microbiology and biotechnology , zoology
Language(s)English
SCImago Journal Rank1.495
H-Index131
eISSN1613-4133
pISSN1613-4125
DOI10.1002/mnfr.201800512

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