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Programming of the Beige Phenotype in White Adipose Tissue of Adult Mice by Mild Resveratrol and Nicotinamide Riboside Supplementations in Early Postnatal Life
Author(s) -
Serrano Alba,
Asnani-Kishnani Madhu,
Rodríguez Ana María,
Palou Andreu,
Ribot Joan,
Bonet María Luisa
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201800463
Subject(s) - white adipose tissue , medicine , endocrinology , leptin , adipose tissue , resveratrol , brown adipose tissue , biology , lactation , adiponectin , nicotinamide , obesity , insulin resistance , pregnancy , biochemistry , genetics , enzyme
Scope Resveratrol (RSV) and nicotinamide riboside (NR) are food compounds with anti‐obesity actions in adult rodents. Here, the long‐term effects of RSV and NR mild supplementation throughout lactation on adiposity‐related parameters and the appearance of the beige phenotype in white adipose tissue (WAT) in adulthood are assessed. Methods and results Newborn mice received orally RSV or NR from day 2 to 20 of life. Control littermates received the vehicle. All animals are weaned onto a chow diet on day 21. On day 90, half the animals of each group are assigned to a high‐fat diet (HFD) for 10 weeks, while the other remained on a normal‐fat diet. Energy‐balance‐related parameters, blood parameters, and gene expression and immunohistochemical analysis of WAT are assessed. Treated male mice show an improved response to the HFD, such as delayed body weight gain, a blunted increase in the plasma leptin/adiponectin ratio, and a decreased lipolytic response, together with signs of white‐to‐brown fat remodeling in inguinal WAT. These effects are absent in female mice. Conclusion RSV and NR supplementations in early postnatal life affect WAT's thermogenic/oxidative transcriptional phenotype and metabolic responses in adulthood, with upregulatory and beneficial effects evidenced in male animals.