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Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
Author(s) -
Ulaszewska Marynka M.,
Weinert Christoph H.,
Trimigno Alessia,
Portmann Reto,
Andres Lacueva Cristina,
Badertscher René,
Brennan Lorraine,
Brunius Carl,
Bub Achim,
Capozzi Francesco,
Cialiè Rosso Marta,
Cordero Chiara E.,
Daniel Hannelore,
Durand Stéphanie,
Egert Bjoern,
Ferrario Paola G.,
Feskens Edith J.M.,
Franceschi Pietro,
GarciaAloy Mar,
Giacomoni Franck,
Giesbertz Pieter,
GonzálezDomínguez Raúl,
Hanhineva Kati,
Hemeryck Lieselot Y.,
Kopka Joachim,
Kulling Sabine E.,
Llorach Rafael,
Manach Claudine,
Mattivi Fulvio,
Migné Carole,
Münger Linda H.,
Ott Beate,
Picone Gianfranco,
Pimentel Grégory,
PujosGuillot Estelle,
Riccadonna Samantha,
Rist Manuela J.,
Rombouts Caroline,
Rubert Josep,
Skurk Thomas,
Sri Harsha Pedapati S. C.,
Meulebroek Lieven,
Vanhaecke Lynn,
VázquezFresno Rosa,
Wishart David,
Vergères Guy
Publication year - 2019
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201800384
Subject(s) - metabolomics , workflow , data science , computer science , biology , bioinformatics , database
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state‐of‐the‐art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative “A Healthy Diet for a Healthy Life” (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful “tips and tricks” along the analytical workflow.