Premium
Long‐Term Genistein Consumption Modifies Gut Microbiota, Improving Glucose Metabolism, Metabolic Endotoxemia, and Cognitive Function in Mice Fed a High‐Fat Diet
Author(s) -
López Patricia,
Sánchez Mónica,
PerezCruz Claudia,
VelázquezVillegas Laura A.,
Syeda Tauqeerunnisa,
AguilarLópez Miriam,
RochaViggiano Ana K.,
del Carmen SilvaLucero María,
TorreVillalvazo Ivan,
Noriega Lilia G.,
Torres Nimbe,
Tovar Armando R.
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201800313
Subject(s) - genistein , gut flora , endocrinology , medicine , biology , diet induced obese , metabolism , obesity , lipopolysaccharide , metabolic syndrome , insulin resistance , immunology
Scope The aim of this study is to assess whether the long‐term addition of genistein to a high‐fat diet can ameliorate the metabolic and the cognitive alterations and whether the changes can be associated with modifications to the gut microbiota. Methods and results C57/BL6 mice were fed either a control (C) diet, a high‐fat (HF) diet, or a high‐fat diet containing genistein (HFG) for 6 months. During the study, indirect calorimetry, IP glucose tolerance tests, and behavioral analyses were performed. At the end of the study, plasma, liver, brain, and fecal samples were collected. The results showed that mice fed the HFG diet gained less weight, had lower serum triglycerides, and an improvement in glucose tolerance than those fed an HF diet. Mice fed the HFG diet also modified the gut microbiota that was associated with lower circulating levels of lipopolysaccharide (LPS) and reduced expression of pro‐inflammatory cytokines in the liver compared to those fed HF diet. The reduction in LPS by the consumption of genistein was accompanied by an improvement of the cognitive function. Conclusions Genistein is able to regulate the gut microbiota, reducing metabolic endotoxemia and decreasing the neuroinflammatory response despite the consumption of a HF diet.