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Arabinoxylan Attenuates Type 2 Diabetes by Improvement of Carbohydrate, Lipid, and Amino Acid Metabolism
Author(s) -
Nie Qixing,
Chen Haihong,
Hu Jielun,
Gao He,
Fan Linlin,
Long Zhimin,
Nie Shaoping
Publication year - 2018
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201800222
Subject(s) - arabinoxylan , chemistry , type 2 diabetes , medicine , kynurenine , endocrinology , lipid metabolism , diabetes mellitus , metabolism , taurine , biochemistry , amino acid , tryptophan , polysaccharide
Scope Type 2 diabetes is a complex metabolic and endocrine disorder worldwide, which causes severe health and economic problems. The aim of this study is to investigate the molecular mechanisms by which arabinoxylan from Plantago asiatica L. attenuates type 2 diabetes from the perspective of urine metabolomics. Methods and Results High‐fat diet and streptozotocin‐induced type 2 diabetic rats are treated with arabinoxylan, then the urine samples are collected for untargeted metabolomics analysis by UPLC–Triple‐TOF/MS. Diabetes causes significant increases in the levels of acetone, glucose, 2‐oxoglutarate, and leucine, and significant decreases in the concentrations of creatine, histidine, lysine, l ‐tryptophan, hippurate, l ‐cysteine, kynurenine, and arabitol as compared with normal rats ( p < 0.01). And these 12 metabolites (with VIP cut‐off value > 1) can be used as biomarkers in type 2 diabetes. A total of 21 urinary metabolites are significantly improved by arabinoxylan administration in diabetic rats, and these metabolites are mainly involved in TCA cycle, and metabolism of lipid and ketone body, taurine and hypotaurine, tryptophan, and branched chain amino acids. Conclusion Arabinoxylan administration improves carbohydrate, lipid, and amino acid metabolism in type 2 diabetic rats, which provide important insights into the mechanisms underlying type 2 diabetes as well as the effects of arabinoxylan.