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Back cover: Gastrointestinal digestion of hazelnut allergens on molecular level: Elucidation of degradation kinetics and resistant immunoactive peptides using mass spectrometry
Author(s) -
Korte Robin,
Bräcker Julia,
Brockmeyer Jens
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201770104
Subject(s) - digestion (alchemy) , chemistry , gastrointestinal tract , allergy , sensitization , allergen , kinetics , in vitro , food allergy , mass spectrometry , food allergens , food science , biochemistry , chromatography , biology , immunology , physics , quantum mechanics
Mol. Nutr. Food Res . 2017, 61 , 1700130. DOI: 10.1002/mnfr.201700130 Sensitization to hazelnut allergens via the gastrointestinal tract has been associated with severe clinical symptoms. Therefore, the biochemical fate of six relevant hazelnut allergens undergoing digestion is studied in vitro. Product structures and digestion kinetics are elucidated by HPLC‐MS/MS. 1183 digestion resistant peptides are characterized that may represent sensitizers or elicitors for hazelnut allergy, and a comprehensive insight into the molecular dynamics of the proteolytic degradation of plant food allergens is provided.