Premium
Front cover: Exacerbation of liver steatosis following exposure to famine and overnutrition
Author(s) -
Ning Zhiyuan,
Zhang Kun,
Zhao Li,
Lu You,
Sun Honglin,
Chen Chi,
Nie Xiaomin,
Lu Meng,
Wang Ningjian,
Lu Yingli
Publication year - 2017
Publication title -
molecular nutrition and food research
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.495
H-Index - 131
eISSN - 1613-4133
pISSN - 1613-4125
DOI - 10.1002/mnfr.201770101
Subject(s) - steatosis , overnutrition , lipogenesis , lipotoxicity , medicine , endocrinology , gluconeogenesis , fatty liver , biology , insulin , insulin resistance , malnutrition , metabolism , disease
Mol. Nutr. Food Res . 2017, 61 , 1700097. DOI: 10.1002/mnfr.201700097 Food restriction in early life, the first hit, leads to increased gluconeogenesis and decreased muscle glucose uptake. This may induce elevated glucose flux into the liver and liver fatty acid synthetase expression, which further leads to enhanced de novo lipogenesis and steatosis. Furthermore, overnutrition, the second hit in later life, exacerbates liver steatosis.